Khe or KHE may refer to:
- Khē, Arabic letter
- Khe language, a language of Burkina Faso
- Khe, the name of the Nepali language among the Newar people
- Kaposiform hemangioendothelioma, a tumor
- Kherson International Airport, Kherson Oblast, Ukraine (IATA code)
- Khe, a raw fish dish of Koryo-saram cuisine based on the Korean dish hoe