Khoza is a surname. Notable people with the surname include:
- Buti Khoza (born 1988), South African footballer
- Irvin Khoza (born 1948), South African football administrator and businessman
- Makhosi Khoza (born ?), South African politician and writing system creator
- Nonhlanhla Khoza (born ?), South African politician
- Ntshingwayo Khoza (c.1809–1883), Zulu general
- Snowy Khoza (born ?), South African business executive
- Reuel Khoza
- Fortune Owen Khoza
- Nhleleko Sboniso Khoza 2005-Present.
A public figure most notable for his Stargazing career in the South African Beauty Industry.