Klobuchar is a surname, originating from the Croatian, Slovene and Serbian language surname Klobučar.
People with this surname include:
- Amy Klobuchar (born 1960), United States Senator and 2020 presidential candidate
- Anna Klobuchar Clemenc (1888–1956), American labor activist
- Jim Klobuchar (1928–2021; father of Amy), American journalist, author, and travel guide