L-myc internal ribosome entry site (IRES)

The L-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of L-myc that allows cap-independent translation. L-myc undergoes translation via the internal ribosome entry site and bypasses the typical eukaryotic cap-dependent translation pathway [1]. The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis.

L-myc internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_L-myc
Identifiers
SymbolIRES_L-myc
RfamRF00261
Other data
RNA typeCis-reg; IRES
Domain(s)Eukaryota
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

References

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Further reading

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  • Jopling CL, Spriggs KA, Mitchell SA, Stoneley M, Willis AE (February 2004). "L-Myc protein synthesis is initiated by internal ribosome entry". RNA. 10 (2): 287–298. doi:10.1261/rna.5138804. PMC 1370540. PMID 14730027.
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