L-olivosyl-oleandolide 3-O-methyltransferase (EC 2.1.1.239, OleY) is an enzyme with systematic name S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase.[1] This enzyme catalyses the following chemical reaction
| L-olivosyl-oleandolide 3-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.239 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- S-adenosyl-L-methionine + L-olivosyl-oleandolide S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide
The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus.
References
edit- ^ Rodríguez L, Rodríguez D, Olano C, Braña AF, Méndez C, Salas JA (September 2001). "Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus". Journal of Bacteriology. 183 (18): 5358–63. doi:10.1128/jb.183.18.5358-5363.2001. PMC 95419. PMID 11514520.
External links
edit- L-olivosyl-oleandolide+3-O-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
