L4 ribosomal protein leader

An L4 ribosomal protein leader is a ribosomal protein leader involved in ribosome biogenesis. It is used as an autoregulatory mechanism to control the concentration of the ribosomal protein L4. Known Examples were predicted in Archaeoglobi with bioinformatic approaches.[1] The structure is located in the 5′ untranslated regions of mRNAs encoding ribosomal proteins L3 (rplC), L4 (rplD), L23 (rplW) and L2 (rplB).[1]

Ribosomal L4 leader
Predicted secondary structure and sequence conservation of L4_leader. This picture was adapted from a previous publication. [1]
Identifiers
SymbolL4
Other data
RNA typeCis-reg; leader
Domain(s)Archaea
PDB structuresPDBe

References

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  1. ^ a b c Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130): 130. doi:10.1186/s12866-020-01823-6. PMC 7247131. PMID 32448158.
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