LAIR2

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.

LAIR2
Identifiers
Aliases	LAIR2, CD306, leukocyte associated immunoglobulin like receptor 2
External IDs	OMIM: 602993; HomoloGene: 88663; GeneCards: LAIR2; OMA:LAIR2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.42 Start 54,497,879 bp End 54,510,687 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte placenta blood lymph node appendix monocyte bone marrow spleen right coronary artery right lung n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component extracellular region Biological process regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3904 n/a Ensembl ENSG00000167618 ENSG00000275819 ENSG00000277335 ENSG00000274084 n/a UniProt Q6ISS4 n/a RefSeq (mRNA) NM_002288 NM_021270 n/a RefSeq (protein) NP_002279 NP_067154 n/a Location (UCSC) Chr 19: 54.5 – 54.51 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Lebbink RJ, van den Berg MC, de Ruiter T, Raynal N, Van Roon JA, Lenting PJ, Jin B, Meyaard L (2008). "The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction". J. Immunol. 180 (3): 1662–9. doi:10.4049/jimmunol.180.3.1662. PMID 18209062.
• Denoeud F, Kapranov P, Ucla C, Frankish A, Castelo R, Drenkow J, Lagarde J, Alioto T, Manzano C (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
• Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. doi:10.4049/jimmunol.162.10.5800. PMID 10229813.
• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, Dubuque T, Favello A (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.