LAPTM4A

Lysosomal protein transmembrane 4 alpha is a protein that in humans is encoded by the LAPTM4A gene.

LAPTM4A
Identifiers
Aliases	LAPTM4A, HUMORF13, LAPTM4, MBNT, Mtrp, lysosomal protein transmembrane 4 alpha
External IDs	MGI: 108017; HomoloGene: 7427; GeneCards: LAPTM4A; OMA:LAPTM4A - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p24.1 Start 20,032,650 bp End 20,051,628 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 A1.1 Start 8,971,664 bp End 8,988,742 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula skin of hip germinal epithelium synovial joint urethra caput epididymis Epithelium of choroid plexus mucosa of paranasal sinus tail of epididymis superficial temporal artery Top expressed in corneal stroma calvaria choroid plexus of fourth ventricle molar seminal vesicula extensor digitorum longus muscle extraocular muscle right lung lactiferous gland umbilical cord More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component endomembrane system integral component of membrane Golgi apparatus membrane lysosomal membrane late endosome membrane Biological process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9741 17775 Ensembl ENSG00000068697 ENSMUSG00000020585 UniProt Q15012 Q60961 RefSeq (mRNA) NM_014713 NM_008640 RefSeq (protein) NP_055528 n/a Location (UCSC) Chr 2: 20.03 – 20.05 Mb Chr 12: 8.97 – 8.99 Mb PubMed search
Wikidata
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Function

This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.