Leucine carboxyl methyltransferase 2 is an enzyme that in humans is encoded by the LCMT2 gene.[5][6][7]

LCMT2
Identifiers
AliasesLCMT2, PPM2, TYW4, leucine carboxyl methyltransferase 2
External IDsOMIM: 611246; MGI: 1353659; HomoloGene: 19642; GeneCards: LCMT2; OMA:LCMT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014793

NM_177846

RefSeq (protein)

NP_055608

NP_808514

Location (UCSC)Chr 15: 43.32 – 43.33 MbChr 2: 120.96 – 120.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this intronless gene belongs to the methyltransferase superfamily and acts as a G1/S and G2/M phase checkpoint regulator. It has been hypothesized that cigarette smoke-induced oxidative stress and transforming growth factor beta 1 may inhibit cellular proliferation by modulating the expression of this protein.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168806Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074890Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  6. ^ Noma A, Suzuki T (Dec 2006). "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf). 50 (50): 65–6. doi:10.1093/nass/nrl032. PMID 17150819.
  7. ^ a b "Entrez Gene: LCMT2 leucine carboxyl methyltransferase 2".

Further reading

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