LCP1

Plastin-2 is a protein that in humans is encoded by the LCP1 gene.

LCP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D85
Identifiers
Aliases	LCP1, CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, lymphocyte cytosolic protein 1
External IDs	OMIM: 153430; MGI: 104808; HomoloGene: 80174; GeneCards: LCP1; OMA:LCP1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q14.13 Start 46,125,920 bp End 46,211,871 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 D3|14 39.63 cM Start 75,368,541 bp End 75,468,282 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood bone marrow cells spleen appendix corpus epididymis trabecular bone gallbladder right lung Top expressed in granulocyte spleen tibiofemoral joint mesenteric lymph nodes thymus stroma of bone marrow yolk sac parotid gland blood seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding actin filament binding identical protein binding GTPase binding actin binding integrin binding Cellular component cytoplasm cytosol cell projection membrane focal adhesion filopodium ruffle plasma membrane stress fiber ruffle membrane actin filament actin cytoskeleton actin filament bundle podosome phagocytic cup extracellular exosome cytoskeleton extracellular space cell junction perinuclear region of cytoplasm Biological process extracellular matrix disassembly positive regulation of podosome assembly actin filament bundle assembly regulation of intracellular protein transport animal organ regeneration protein kinase A signaling cell migration wound healing, spreading of cells T cell activation involved in immune response actin filament network formation actin crosslink formation interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3936 18826 Ensembl ENSG00000136167 ENSMUSG00000021998 UniProt P13796 Q61233 RefSeq (mRNA) NM_002298 NM_001247984 NM_008879 RefSeq (protein) NP_002289 NP_002289.2 NP_001234913 NP_032905 Location (UCSC) Chr 13: 46.13 – 46.21 Mb Chr 14: 75.37 – 75.47 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

Further reading

• Namba Y, Ito M, Zu Y, Shigesada K, Maruyama K (October 1992). "Human T cell L-plastin bundles actin filaments in a calcium-dependent manner". Journal of Biochemistry. 112 (4): 503–7. doi:10.1093/oxfordjournals.jbchem.a123929. PMID 1491005.
• Zu YL, Shigesada K, Nishida E, Kubota I, Kohno M, Hanaoka M, Namba Y (September 1990). "65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites". Biochemistry. 29 (36): 8319–24. doi:10.1021/bi00488a017. PMID 2252891.
• Lin CS, Aebersold RH, Leavitt J (April 1990). "Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain". Molecular and Cellular Biology. 10 (4): 1818–21. doi:10.1128/MCB.10.4.1818. PMC 362293. PMID 2378651.
• Lin CS, Aebersold RH, Kent SB, Varma M, Leavitt J (November 1988). "Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts". Molecular and Cellular Biology. 8 (11): 4659–68. doi:10.1128/MCB.8.11.4659. PMC 365555. PMID 3211125.
• Matsushima K, Shiroo M, Kung HF, Copeland TD (May 1988). "Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1". Biochemistry. 27 (10): 3765–70. doi:10.1021/bi00410a037. PMID 3261603.
• Kondo I, Shin K, Honmura S, Nakajima H, Yamamura E, Satoh H, Terauchi M, Usuki Y, Takita H, Hamaguchi H (1986). "A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13". Human Genetics. 71 (3): 263–6. doi:10.1007/BF00284588. PMID 3864729. S2CID 11261385.
• Arpin M, Friederich E, Algrain M, Vernel F, Louvard D (December 1994). "Functional differences between L- and T-plastin isoforms". The Journal of Cell Biology. 127 (6 Pt 2): 1995–2008. doi:10.1083/jcb.127.6.1995. PMC 2120298. PMID 7806577.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Lin CS, Shen W, Chen ZP, Tu YH, Matsudaira P (April 1994). "Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney". Molecular and Cellular Biology. 14 (4): 2457–67. doi:10.1128/mcb.14.4.2457. PMC 358613. PMID 8139549.
• Lin CS, Park T, Chen ZP, Leavitt J (February 1993). "Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells". The Journal of Biological Chemistry. 268 (4): 2781–92. doi:10.1016/S0021-9258(18)53842-4. PMID 8428952.
• Lin CS, Chen ZP, Park T, Ghosh K, Leavitt J (February 1993). "Characterization of the human L-plastin gene promoter in normal and neoplastic cells". The Journal of Biological Chemistry. 268 (4): 2793–801. doi:10.1016/S0021-9258(18)53843-6. PMID 8428953.
• Jones SL, Brown EJ (June 1996). "FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils". The Journal of Biological Chemistry. 271 (24): 14623–30. doi:10.1074/jbc.271.24.14623. PMID 8663066.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Okumura Y, Yano M, Murakami M, Mori S, Towatari T, Kido H (January 1999). "The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin". FEBS Letters. 442 (1): 39–42. doi:10.1016/S0014-5793(98)01612-3. PMID 9923600. S2CID 40872647.
• Wang J, Brown EJ (August 1999). "Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A". The Journal of Biological Chemistry. 274 (34): 24349–56. doi:10.1074/jbc.274.34.24349. PMID 10446213.
• Lin CS, Lau A, Yeh CC, Chang CH, Lue TF (January 2000). "Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences". DNA and Cell Biology. 19 (1): 1–7. doi:10.1089/104454900314654. PMID 10668786.
• Jia J, Han Q, Borregaard N, Lollike K, Cygler M (July 2000). "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family". Journal of Molecular Biology. 300 (5): 1271–81. doi:10.1006/jmbi.2000.3925. PMID 10903868.
• Lollike K, Johnsen AH, Durussel I, Borregaard N, Cox JA (May 2001). "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner". The Journal of Biological Chemistry. 276 (21): 17762–9. doi:10.1074/jbc.M100965200. PMID 11279160.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.