LDB may refer to:
- Lake railway station, Isle of Wight, from its National Rail code
- Land development bank, a type of bank in India
- Liga de Desenvolvimento de Basquete, a Brazilian under-22 basketball league
- The Little Drummer Boy, a Christmas song, especially in the context of the Little Drummer Boy Challenge, an attempt to avoid hearing the song.
- Liquor Distribution Branch, a governmental body responsible for regulating and monitoring the liquor industry in British Columbia, Canada
- Lordsburg (Amtrak station), Lordsburg, New Mexico, from its Amtrak code
- Long duration ballooning, a program of the Columbia Scientific Balloon Facility
- The Louis D. Brandeis Center for Human Rights under Law (LDB), an organization that advances the civil and human rights of the Jewish people and promotes justice for all
- Kelton "LDB" Kessee (born 1981), drummer of the American R&B group IMx
- Light-dark box test, an animal model used in pharmacology