LEO1

RNA polymerase-associated protein LEO1 is an enzyme that in humans is encoded by the LEO1 gene.

LEO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M6T
Identifiers
Aliases	LEO1, RDL, LEO1 homolog, Paf1/RNA polymerase II complex component
External IDs	OMIM: 610507; MGI: 2685031; HomoloGene: 133895; GeneCards: LEO1; OMA:LEO1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.2 Start 51,938,025 bp End 51,971,778 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 D Start 75,348,806 bp End 75,373,714 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii ventricular zone mucosa of transverse colon ganglionic eminence oocyte rectum islet of Langerhans Achilles tendon internal globus pallidus secondary oocyte Top expressed in otic vesicle tail of embryo genital tubercle neural layer of retina zygote morula hand blastocyst embryo ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II C-terminal domain phosphoserine binding protein binding Cellular component nucleus centrosome Cdc73/Paf1 complex nucleoplasm fibrillar center Biological process negative regulation of myeloid cell differentiation positive regulation of mRNA 3'-end processing mRNA polyadenylation endodermal cell fate commitment Wnt signaling pathway histone H2B ubiquitination stem cell population maintenance regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription, DNA-templated histone monoubiquitination positive regulation of transcription elongation from RNA polymerase II promoter histone modification beta-catenin-TCF complex assembly transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 123169 235497 Ensembl ENSG00000166477 ENSMUSG00000042487 UniProt Q8WVC0 Q5XJE5 RefSeq (mRNA) NM_001286430 NM_138792 NM_001323903 NM_001323904 NM_001006122 NM_001039522 RefSeq (protein) NP_001273359 NP_001310832 NP_001310833 NP_620147 NP_001034611 Location (UCSC) Chr 15: 51.94 – 51.97 Mb Chr 9: 75.35 – 75.37 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhao L, Tong T, Zhang Z (2005). "Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts". FASEB J. 19 (6): 521–32. doi:10.1096/fj.04-2689com. PMID 15791002. S2CID 6839737.
• Mosimann C, Hausmann G, Basler K (2006). "Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo". Cell. 125 (2): 327–41. doi:10.1016/j.cell.2006.01.053. PMID 16630820.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.