LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.[5][6][7]

LHX3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLHX3, CPHD3, LIM3, M2-LIM homeobox 3
External IDsOMIM: 600577; MGI: 102673; HomoloGene: 7814; GeneCards: LHX3; OMA:LHX3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014564
NM_178138
NM_001363746

NM_001039653
NM_010711

RefSeq (protein)

NP_055379
NP_835258
NP_001350675

NP_001034742
NP_034841

Location (UCSC)Chr 9: 136.2 – 136.21 MbChr 2: 26.09 – 26.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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LHX3 encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.[7]

Clinical significance

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Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.[7]

Interactions

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LHX3 has been shown to interact with Ldb1.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107187Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026934Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sloop KW, Meier BC, Bridwell JL, Parker GE, Schiller AM, Rhodes SJ (Jan 2000). "Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties". Mol Endocrinol. 13 (12): 2212–25. doi:10.1210/me.13.12.2212. PMID 10598593.
  6. ^ Sloop KW, Showalter AD, Von Kap-Herr C, Pettenati MJ, Rhodes SJ (May 2000). "Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9". Gene. 245 (2): 237–43. doi:10.1016/S0378-1119(00)00025-1. PMID 10717474.
  7. ^ a b c "Entrez Gene: LHX3 LIM homeobox 3".
  8. ^ Jurata LW, Pfaff SL, Gill GN (February 1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. PMID 9452425.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.