LHX6

LIM/homeobox protein Lhx6 is a protein that in humans is encoded by the LHX6 gene.

LHX6
Identifiers
Aliases	LHX6, LHX6.1, LIM homeobox 6, hLHX6
External IDs	OMIM: 608215; MGI: 1306803; HomoloGene: 7401; GeneCards: LHX6; OMA:LHX6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q33.2 Start 122,202,577 bp End 122,229,626 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 B Start 35,971,965 bp End 35,995,420 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad subcutaneous adipose tissue prefrontal cortex anterior cingulate cortex endothelial cell orbitofrontal cortex Brodmann area 46 ganglionic eminence visceral pleura parietal pleura Top expressed in medial ganglionic eminence maxillary prominence molar entorhinal cortex barrel cortex CA3 field perirhinal cortex mandibular prominence globus pallidus female urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus Biological process multicellular organism development cerebral cortex GABAergic interneuron migration cell differentiation regulation of transcription, DNA-templated cerebral cortex radially oriented cell migration cerebral cortex tangential migration cell maturation transcription, DNA-templated nervous system development regulation of transcription by RNA polymerase II forebrain neuron development neuron differentiation positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26468 16874 Ensembl ENSG00000106852 ENSMUSG00000026890 UniProt Q9UPM6 Q9R1R0 RefSeq (mRNA) NM_001242333 NM_001242334 NM_001242335 NM_014368 NM_199160 NM_001348190 NM_001083125 NM_001083126 NM_001083127 NM_008500 NM_001355125 RefSeq (protein) NP_001229262 NP_001229263 NP_001229264 NP_055183 NP_954629 NP_001335119 NP_001229263.1 NP_001076594 NP_001076595 NP_001076596 NP_032526 NP_001342054 Location (UCSC) Chr 9: 122.2 – 122.23 Mb Chr 2: 35.97 – 36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Estécio MR, Youssef EM, Rahal P, et al. (2006). "LHX6 is a sensitive methylation marker in head and neck carcinomas". Oncogene. 25 (36): 5018–26. doi:10.1038/sj.onc.1209509. PMID 16732332. S2CID 10501427.