LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.[5]

LMO4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLMO4, LIM domain only 4
External IDsOMIM: 603129; MGI: 109360; HomoloGene: 4927; GeneCards: LMO4; OMA:LMO4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006769
NM_001369491

NM_001161769
NM_001161770
NM_010723

RefSeq (protein)

NP_006760
NP_001356420

NP_001155241
NP_001155242
NP_034853

Location (UCSC)Chr 1: 87.33 – 87.35 MbChr 3: 143.89 – 143.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.[5]

Interactions

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LMO4 has been shown to interact with LDB1,[6][7] RBBP8[6][8] and BRCA1.[6][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143013Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028266Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: LMO4 LIM domain only 4".
  6. ^ a b c Sutherland, Kate D; Visvader Jane E; Choong David Y H; Sum Eleanor Y M; Lindeman Geoffrey J; Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi:10.1002/ijc.11343. ISSN 0020-7136. PMID 12925972.
  7. ^ Deane, Janet E; Mackay Joel P; Kwan Ann H Y; Sum Eleanor Y M; Visvader Jane E; Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN 0261-4189. PMC 156068. PMID 12727888.
  8. ^ a b Sum, Eleanor Y M; Peng Benjamin; Yu Xin; Chen Junjie; Byrne Jennifer; Lindeman Geoffrey J; Visvader Jane E (Mar 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. ISSN 0021-9258. PMID 11751867.

Further reading

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