LPU may refer to:
- Least publishable unit, the smallest amount of information that can generate a publication in a peer-reviewed journal
- General Elections Institution (Lembaga Pemilihan Umum), former election organizer in Indonesia
- Linkin Park Underground, the fan club of an American rock band
- London and Provincial Union of Licensed Vehicle Workers, former British trade union
- Lovely Professional University, a university in Jalandhar, Punjab, India
- Lyceum of the Philippines University, a private and autonomous university in the Philippines.
- Local Processing Unit, used for PLC
- LPU (Language Processing Unit) for AI