LPXN

Leupaxin is a protein that in humans is encoded by the LPXN gene.

LPXN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X3H, 4XEF, 4XEK, 4XEV
Identifiers
Aliases	LPXN, LDPL, leupaxin
External IDs	OMIM: 605390; MGI: 2147677; HomoloGene: 3536; GeneCards: LPXN; OMA:LPXN - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.1 Start 58,526,871 bp End 58,578,220 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 12,773,557 bp End 12,811,171 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus granulocyte mononuclear cell monocyte appendix lymph node blood spleen mucosa of ileum epithelium of nasopharynx Top expressed in mesenteric lymph nodes spermatocyte stroma of bone marrow spleen thymus seminiferous tubule blood spermatid medulla of thymus subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transcription coregulator activity metal ion binding Cellular component cytoplasm perinuclear region of cytoplasm podosome cell junction plasma membrane cell projection nucleus focal adhesion membrane cytosol nuclear speck Biological process negative regulation of B cell receptor signaling pathway negative regulation of cell adhesion cell adhesion regulation of cell adhesion mediated by integrin regulation of transcription, DNA-templated transcription, DNA-templated signal transduction protein-containing complex assembly regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9404 107321 Ensembl ENSG00000110031 ENSMUSG00000024696 UniProt O60711 Q99N69 RefSeq (mRNA) NM_001143995 NM_001307951 NM_004811 NM_134152 NM_001361971 RefSeq (protein) NP_001137467 NP_001294880 NP_004802 NP_598913 NP_001348900 Location (UCSC) Chr 11: 58.53 – 58.58 Mb Chr 19: 12.77 – 12.81 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.

Further reading

• Chew V, Lam KP (2007). "Leupaxin negatively regulates B cell receptor signaling". J. Biol. Chem. 282 (37): 27181–91. doi:10.1074/jbc.M704625200. PMID 17640867.
• Sahu SN, Nunez S, Bai G, Gupta A (2007). "Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells". Am. J. Physiol., Cell Physiol. 292 (6): C2288–96. doi:10.1152/ajpcell.00503.2006. PMID 17329398.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
• Watanabe N, Amano N, Ishizuka H, Mashima K (2005). "Leupaxin binds to PEST domain tyrosine phosphatase PEP". Mol. Cell. Biochem. 269 (1–2): 13–7. doi:10.1007/s11010-005-2149-6. PMID 15786712. S2CID 21854825.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Gupta A, Lee BS, Khadeer MA, et al. (2003). "Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast". J. Bone Miner. Res. 18 (4): 669–85. doi:10.1359/jbmr.2003.18.4.669. PMID 12674328. S2CID 24743841.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu S, Thomas SM, Woodside DG, et al. (2000). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature. 402 (6762): 676–81. doi:10.1038/45264. PMID 10604475. S2CID 2770368.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.