LRRC4

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.

LRRC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DL9, 3ZYI
Identifiers
Aliases	LRRC4, NGL-2, NAG14, leucine rich repeat containing 4
External IDs	OMIM: 610486; MGI: 2182081; HomoloGene: 36403; GeneCards: LRRC4; OMA:LRRC4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q32.1 Start 128,027,071 bp End 128,032,107 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A3.3 Start 28,661,830 bp End 28,831,746 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone prefrontal cortex right frontal lobe bronchial epithelial cell dorsolateral prefrontal cortex Brodmann area 9 right hemisphere of cerebellum cingulate gyrus anterior cingulate cortex cerebellar vermis Top expressed in interventricular septum dentate gyrus of hippocampal formation granule cell visual cortex primary visual cortex piriform cortex cingulate gyrus superior frontal gyrus lobe of cerebellum hippocampus proper primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase inhibitor activity protein binding Cellular component cytoplasm integral component of membrane neuron spine cell junction postsynaptic membrane dendritic spine plasma membrane synapse excitatory synapse membrane Schaffer collateral - CA1 synapse glutamatergic synapse integral component of postsynaptic density membrane Biological process synapse organization postsynaptic density protein 95 clustering regulation of synapse organization negative regulation of protein kinase activity cytokine-mediated signaling pathway negative regulation of receptor signaling pathway via JAK-STAT modulation of chemical synaptic transmission synaptic membrane adhesion excitatory synapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64101 192198 Ensembl ENSG00000128594 ENSMUSG00000049939 UniProt Q9HBW1 Q99PH1 RefSeq (mRNA) NM_022143 NM_138682 RefSeq (protein) NP_071426 NP_619623 Location (UCSC) Chr 7: 128.03 – 128.03 Mb Chr 6: 28.66 – 28.83 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. Also it has been identified as a possible pathogenic gene involved in the neurogenic inflammation in rosacea.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nakashiba T, Ikeda T, Nishimura S, et al. (2000). "Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins". J. Neurosci. 20 (17): 6540–50. doi:10.1523/JNEUROSCI.20-17-06540.2000. PMC 6772945. PMID 10964959.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Lin JC, Ho WH, Gurney A, Rosenthal A (2004). "The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons". Nat. Neurosci. 6 (12): 1270–6. doi:10.1038/nn1148. PMID 14595443. S2CID 28353131.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Q, Wang J, Fan S, et al. (2005). "Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily". FEBS Lett. 579 (17): 3674–82. doi:10.1016/j.febslet.2005.05.058. PMID 15967442. S2CID 19888187.
• Zhang QH, Wang LL, Cao L, et al. (2005). "Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system". Acta Biochim. Biophys. Sin. (Shanghai). 37 (8): 532–40. doi:10.1111/j.1745-7270.2005.00079.x. PMID 16077900.
• Fan SQ, Wang JR, Huang H, et al. (2007). "[Function of a novel brain-specific gene LRRC4]". Zhonghua Zhong Liu Za Zhi. 27 (7): 393–6. PMID 16188120.
• Zhang QH, Wu MH, Wang LL, et al. (2005). "Profiling of differentially expressed genes in LRRC4 overexpressed glioblastoma cells by cDNA array". Acta Biochim. Biophys. Sin. (Shanghai). 37 (10): 680–7. doi:10.1111/j.1745-7270.2005.00100.x. PMID 16215635.
• Wu M, Huang C, Gan K, et al. (2006). "LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway". Mol. Biol. Cell. 17 (8): 3534–42. doi:10.1091/mbc.E05-11-1082. PMC 1525233. PMID 16723503.
• Wu M, Gan K, Huang C, et al. (2007). "LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression". J. Neurooncol. 80 (2): 133–42. doi:10.1007/s11060-006-9173-6. PMID 16941076. S2CID 30590797.
• Wu M, Huang C, Li X, et al. (2007). "LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses". J. Cell. Physiol. 214 (1): 65–74. doi:10.1002/jcp.21163. PMID 17541939. S2CID 44665033.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9HBW1 (Leucine-rich repeat-containing protein 4) at the PDBe-KB.
• Role of LRRC4 in Rosacea