Leucine-rich repeat-containing protein 8C is a protein that in humans is encoded by the LRRC8C gene .[ 5] LRRC8A , LRRC8B , LRRC8D , and LRRC8E , is sometimes a subunit of the heteromer protein Volume-Regulated Anion Channel .[ 6] [ 7]
While LRRC8C is one of many proteins that can be part of VRAC, research has found that it is not as crucial to the activity of the channel in comparison to LRRC8A and LRRC8D .[ 8] [ 9] [ 10] LRRC8A and LRRC8D are necessary for VRAC function, other studies have found that they are not sufficient for the full range of usual VRAC activity.[ 11] [ 12] [ 10]
In addition to its role in VRACs, the LRRC8 protein family is also associated with agammaglobulinemia -5.[ 13]
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