Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene.[5][6]

LRRN2
Identifiers
AliasesLRRN2, FIGLER7, GAC1, LRANK1, LRRN5, leucine rich repeat neuronal 2
External IDsOMIM: 605492; MGI: 106037; HomoloGene: 21274; GeneCards: LRRN2; OMA:LRRN2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006338
NM_201630

NM_010732

RefSeq (protein)

NP_006329
NP_963924

NP_034862

Location (UCSC)Chr 1: 204.62 – 204.69 MbChr 1: 132.81 – 132.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170382Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026443Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Almeida A, Zhu XX, Vogt N, Tyagi R, Muleris M, Dutrillaux AM, Dutrillaux B, Ross D, Malfoy B, Hanash S (Aug 1998). "GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas". Oncogene. 16 (23): 2997–3002. doi:10.1038/sj.onc.1201828. PMID 9662332.
  6. ^ a b "Entrez Gene: LRRN2 leucine rich repeat neuronal 2".

Further reading

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