Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene .[ 5] [ 6]
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000170382 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026443 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Almeida A, Zhu XX, Vogt N, Tyagi R, Muleris M, Dutrillaux AM, Dutrillaux B, Ross D, Malfoy B, Hanash S (Aug 1998). "GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas" . Oncogene . 16 (23): 2997–3002. doi :10.1038/sj.onc.1201828 PMID 9662332 . ^ a b "Entrez Gene: LRRN2 leucine rich repeat neuronal 2" .
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