U6 snRNA-associated Sm-like protein LSm5 is a protein that in humans is encoded by the LSM5 gene .[ 5] [ 6] [ 7]
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif , which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing .[supplied by OMIM][ 7]
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