U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene .[ 5] [ 6] [ 7]
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2 ; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop.
The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000164167 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031683 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin" . EMBO J . 18 (12): 3451–62. doi :10.1093/emboj/18.12.3451 . PMC 1171424 PMID 10369684 . ^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro" . EMBO J . 18 (20): 5789–802. doi :10.1093/emboj/18.20.5789 . PMC 1171645 PMID 10523320 . ^ a b "Entrez Gene: LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)" .
Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)" . J. Biol. Chem . 275 (34): 26370–5. doi :10.1074/jbc.M003299200 PMID 10851237 . Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera" . Arthritis Rheum . 46 (3): 726–34. doi :10.1002/art.10220 PMID 11920408 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci" . RNA . 8 (12): 1489–501. doi :10.1017/S1355838202021726 . PMC 1370355 PMID 12515382 . Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation" . Genome Res . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
