LUC7L3

LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.

LUC7L3
Identifiers
Aliases	LUC7L3, CRA, CREAP-1, CROP, LUC7A, OA48-18, hLuc7A, LUC7 like 3 pre-mRNA splicing factor
External IDs	OMIM: 609434; MGI: 1914934; HomoloGene: 75056; GeneCards: LUC7L3; OMA:LUC7L3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.33 Start 50,719,565 bp End 50,756,219 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 94,178,716 bp End 94,212,814 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pylorus sural nerve right hemisphere of cerebellum endothelial cell cardia tibia cerebellar vermis left ovary seminal vesicula corpus callosum Top expressed in medullary collecting duct genital tubercle Rostral migratory stream Paneth cell renal corpuscle tail of embryo ciliary body retinal pigment epithelium neural layer of retina fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding mRNA binding RNA binding Cellular component U1 snRNP U2-type prespliceosome nucleus nucleoplasm nuclear speck Biological process mRNA processing mRNA splice site selection RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51747 67684 Ensembl ENSG00000108848 ENSMUSG00000020863 UniProt O95232 Q5SUF2 RefSeq (mRNA) NM_006107 NM_016424 NM_001330330 NM_026313 NM_001361573 NM_001361574 NM_001361575 RefSeq (protein) NP_001317259 NP_006098 NP_057508 NP_080589 NP_001348502 NP_001348503 NP_001348504 Location (UCSC) Chr 17: 50.72 – 50.76 Mb Chr 11: 94.18 – 94.21 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). The N-terminal half of the CROP contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

External links

• Human LUC7L3 genome location and LUC7L3 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nishii Y, Morishima M, Kakehi Y, et al. (2000). "CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line". FEBS Lett. 465 (2–3): 153–6. doi:10.1016/S0014-5793(99)01744-5. PMID 10631324. S2CID 7918526.
• Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells". J. Biomed. Sci. 7 (2): 152–9. doi:10.1007/BF02256622. PMID 10754390.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Umehara H, Nishii Y, Morishima M, et al. (2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/S0006-291X(02)03017-6. PMID 12565863.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Brown V, Brown RA, Ozinsky A, et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains". Eur. J. Immunol. 36 (3): 742–53. doi:10.1002/eji.200535158. PMC 2762736. PMID 16482509.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Puig O, Bragado-Nilsson E, Koski T, Séraphin B (2007). "The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human". Nucleic Acids Res. 35 (17): 5874–85. doi:10.1093/nar/gkm505. PMC 2034479. PMID 17726058.