Lymphocyte antigen 6 complex, locus G6E (pseudogene) is a protein that in humans is encoded by the LY6G6E gene.[2]
| LY6G6E | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | LY6G6E, C6orf22, G6e, lymphocyte antigen 6 complex, locus G6E (pseudogene), lymphocyte antigen 6 family member G6E | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610437; GeneCards: LY6G6E; OMA:LY6G6E - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
editLY6G6E belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction.[3]
References
edit- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Lymphocyte antigen 6 complex, locus G6E pseudogene)".
- ^ Mallya M, Campbell RD, Aguado B (July 2002). "Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms". Genomics. 80 (1): 113–23. doi:10.1006/geno.2002.6794. PMID 12079290.
Further reading
edit- Mallya M, Campbell RD, Aguado B (October 2006). "Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands". Protein Science. 15 (10): 2244–56. doi:10.1110/ps.062242606. PMC 2242401. PMID 17008713.
- Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD (July 1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". Journal of Immunology. 163 (1): 278–87. doi:10.4049/jimmunol.163.1.278. PMID 10384126.
- Vignal C, Bansal AT, Balding DJ, Binks MH, Dickson MC, Montgomery DS, Wilson AG (January 2009). "Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci". Arthritis and Rheumatism. 60 (1): 53–62. doi:10.1002/art.24138. PMID 19116923.
- "Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium". Nature. 401 (6756): 921–3. October 1999. doi:10.1038/44853. PMID 10553908. S2CID 186243515.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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