LYPLA1

LYPLA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FJ2
Identifiers
Aliases	LYPLA1, APT-1, APT1, LPL-I, LPL1, hAPT1, lysophospholipase I, lysophospholipase 1
External IDs	OMIM: 605599; MGI: 1344588; HomoloGene: 100781; GeneCards: LYPLA1; OMA:LYPLA1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	54,102,017 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	4,918,633 bp
RNA expression pattern
	Top expressed in
	human penis; ; oral cavity; ; gonad; ; vulva; ; right ventricle; ; skin of thigh; ; mucosa of sigmoid colon; ; epithelium of nasopharynx; ; superior surface of tongue; ; biceps brachii;
	Top expressed in
	right kidney; ; gallbladder; ; superior surface of tongue; ; intercostal muscle; ; jejunum; ; epithelium of small intestine; ; cardiac muscle tissue of left ventricle; ; gastrula; ; extensor digitorum longus muscle; ; plantaris muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lysophospholipase activity; hydrolase activity; lipase activity; palmitoyl-(protein) hydrolase activity; carboxylic ester hydrolase activity; protein binding;
Cellular component	cytoplasm; cytosol; extracellular exosome; mitochondrion;
Biological process	protein depalmitoylation; regulation of nitric-oxide synthase activity; negative regulation of Golgi to plasma membrane protein transport; fatty acid metabolic process; lipid metabolism; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	10434
	18777
	ENSG00000120992
	ENSMUSG00000025903
	O75608; Q6IAQ1
	P97823
NM_001279356; NM_001279357; NM_001279358; NM_001279359; NM_001279360;
	NM_006330
	NM_008866; NM_001355712
NP_001266285; NP_001266286; NP_001266287; NP_001266288; NP_001266289;
	NP_006321; NP_006321.1
	NP_032892; NP_001342641
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.^[5]^[6]

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120992 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025903 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA (Apr 1999). "A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization". Biochim Biophys Acta. 1437 (2): 157–69. doi:10.1016/s1388-1981(99)00012-8. PMID 10064899.
^ ^a ^b "Entrez Gene: LYPLA1 lysophospholipase I".

Wang A, Dennis EA (1999). "Mammalian lysophospholipases". Biochim. Biophys. Acta. 1439 (1): 1–16. doi:10.1016/s1388-1981(99)00063-3. PMID 10395961.
Bohn E, Gerke V, Kresse H, et al. (1992). "Annexin II inhibits calcium-dependent phospholipase A1 and lysophospholipase but not triacyl glycerol lipase activities of rat liver hepatic lipase". FEBS Lett. 296 (3): 237–40. doi:10.1016/0014-5793(92)80294-Q. PMID 1531641. S2CID 19633878.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Wang A, Johnson CA, Jones Y, et al. (2000). "Subcellular localization and PKC-dependent regulation of the human lysophospholipase A/acyl-protein thioesterase in WISH cells". Biochim. Biophys. Acta. 1484 (2–3): 207–14. doi:10.1016/s1388-1981(00)00020-2. PMID 10760470. S2CID 24130546.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Devedjiev Y, Dauter Z, Kuznetsov SR, et al. (2001). "Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A." Structure. 8 (11): 1137–46. doi:10.1016/S0969-2126(00)00529-3. PMID 11080636.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120992 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025903 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10064899-5] Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA (Apr 1999). "A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization". Biochim Biophys Acta. 1437 (2): 157–69. doi:10.1016/s1388-1981(99)00012-8. PMID 10064899.

[entrez-6] "Entrez Gene: LYPLA1 lysophospholipase I".

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[6]

[1]

[2]

[3]

[4]

LYPLA1

References

Further reading