La Gioconda (/lə ˌdʒiːəˈkɒndə/ lə JEE-ə-KON-də, Italian: [la dʒoˈkonda]; "the joyful one" [f.]) may refer to:
- Mona Lisa or La Gioconda, a painting by Leonardo da Vinci
- Lisa del Giocondo, the model depicted in da Vinci's painting
- La Gioconda (opera), an 1876 opera by Amilcare Ponchielli
- La Gioconda (play), tragedy by Gabriele d'Annunzio
- La Gioconda (cafe), a former restaurant in London