La Salle or Lassalle is a surname. Notable people with the surname include:
- Gadifer de la Salle (1340–1415), French soldier of Norman origin
- Nicolas de la Salle (died 1710), French colonial governor
- Jean-Baptiste de La Salle (1651–1719), Patron saint of Teachers and Founder of Institute of the Brothers of the Christian Schools
- René-Robert Cavelier, Sieur de La Salle (1643–1687), French explorer of North America
- Antoine Charles Louis de Lasalle (1775–1809), French cavalry general during the French Revolution and Napoleonic Wars
- Ferdinand Lassalle (1825–1864), German-Jewish jurist and socialist political activist
- Joseph P. LaSalle (1916–1983), American mathematician known for the LaSalle invariance principle
- Denise LaSalle (1939-2018), American singer
- Eriq La Salle (born 1962), American actor
- Mick LaSalle (born 1959), movie critic for the San Francisco Chronicle