In molecular biology, the lamprin family of proteins consists of several lamprin proteins from the Sea lamprey Petromyzon marinus. Lamprin, an insoluble non-collagen, non-elastin protein, is the major connective tissue component of the fibrillar extracellular matrix of lamprey annular cartilage.
| Lamprin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Lamprin | ||||||||
| Pfam | PF06403 | ||||||||
| InterPro | IPR009437 | ||||||||
| |||||||||
Although not generally homologous to any other protein, soluble lamprins contain a tandemly repeated peptide sequence (GGLGY), which is present in both silk moth chorion proteins and spider dragline silk. Strong homologies to this repeat sequence are also present in several mammalian and avian elastins. It is thought that these proteins share a structural motif which promotes self-aggregation and fibril formation in proteins through interdigitation of hydrophobic side chains in beta-sheet/beta-turn structures, a motif that has been preserved in recognisable form over several hundred million years of evolution.[1]
References
edit- ^ Robson P, Wright GM, Sitarz E, Maiti A, Rawat M, Youson JH, Keeley FW (January 1993). "Characterization of lamprin, an unusual matrix protein from lamprey cartilage. Implications for evolution, structure, and assembly of elastin and other fibrillar proteins". J. Biol. Chem. 268 (2): 1440–7. doi:10.1016/S0021-9258(18)54095-3. PMID 7678258.
Further reading
edit- Bochicchio B, Pepe A, Tamburro AM (2001). "On (GGLGY) synthetic repeating sequences of lamprin and analogous sequences". Matrix Biol. 20 (4): 243–50. doi:10.1016/s0945-053x(01)00139-1. PMID 11470400.
- Robson P, Wright GM, Youson JH, Keeley FW (2000). "The structure and organization of lamprin genes: multiple-copy genes with alternative splicing and convergent evolution with insect structural proteins". Mol Biol Evol. 17 (11): 1739–52. doi:10.1093/oxfordjournals.molbev.a026272. hdl:1807/680. PMID 11070061.
- Fernandes RJ, Eyre DR (1999). "The elastin-like protein matrix of lamprey branchial cartilage is cross-linked by lysyl pyridinoline". Biochem Biophys Res Commun. 261 (3): 635–40. doi:10.1006/bbrc.1999.1092. PMID 10441478.
- McBurney KM, Keeley FW, Kibenge FS, Wright GM (1996). "Spatial and temporal distribution of lamprin mRNA during chondrogenesis of trabecular cartilage in the sea lamprey". Anat Embryol (Berl). 193 (5): 419–26. doi:10.1007/bf00185873. PMID 8729960. S2CID 11536003.
- McBurney KM, Keeley FW, Kibenge FS, Wrignt GM (1996). "Detection of lamprin mRNA in the anadromous sea lamprey using in situ hybridization". Biotech Histochem. 71 (1): 44–53. doi:10.3109/10520299609117130. PMID 9138528.