Lancaster House may refer to:
- in England
- Lancaster House, a mansion in the St. James's district in the West End of London
- Lancaster House, an Edwardian warehouse on Whitworth Street in Manchester, England
- in the United States
(by state)
- John L. Lancaster House, Mountain View, Arkansas, listed on the NRHP in Stone County, Arkansas
- John Lancaster House (Keene, Kentucky), listed on the NRHP in Jessamine County, Kentucky
- Lancaster House (Stevensville, Montana), listed on the NRHP in Ravalli County, Montana
- King–Lancaster–McCoy–Mitchell House, Bristol, Virginia, listed on the NRHP in Bristol, Virginia
- Judge Columbia Lancaster House, Ridgefield, Washington, listed on the NRHP in Clark County, Washington