Le Pen is a Breton surname (meaning 'the head', 'the chief' or 'the peninsula'). Notable people with the name include:
- Le Pen family, the political family of France under patriarch Jean-Marie Le Pen
- Jean-Marie Le Pen (born 1928), French politician, founder of the National Front party
- Marine Le Pen (born 1968), French politician, daughter of Jean-Marie and leader of the National Rally party
- Marion Maréchal-Le Pen (born 1989), French politician, granddaughter of Jean-Marie and niece of Marine
- Maurice Jules-Marie Le Pen (1889–1919) French airplane designer, designer of the Levy-Le Pen
- Ulrich Le Pen (born 1974), French football player