Left-right determination factor 1

LEFTY1
Identifiers
Aliases	LEFTY1, LEFTB, LEFTYB, left-right determination factor 1
External IDs	OMIM: 603037; MGI: 107405; HomoloGene: 49231; GeneCards: LEFTY1; OMA:LEFTY1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	225,911,382 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	180,765,965 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; body of pancreas; ; rectum; ; testicle; ; gonad; ; endometrium; ; appendix; ; epithelium of colon; ; monocyte; ; cerebellar hemisphere;
	Top expressed in
	neural plate; ; lateral plate mesoderm; ; primitive endoderm; ; Region I of hippocampus proper; ; endothelial cell of lymphatic vessel; ; lip; ; ankle joint; ; embryo; ; islet of Langerhans; ; skin of external ear;
	More reference expression data
	n/a
Gene ontology
Molecular function	transforming growth factor beta receptor binding; cytokine activity; growth factor activity;
Cellular component	extracellular region; extracellular space;
Biological process	regulation of apoptotic process; multicellular organism development; positive regulation of pathway-restricted SMAD protein phosphorylation; heart morphogenesis; determination of left/right symmetry; negative regulation of transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; regulation of MAPK cascade; SMAD protein signal transduction; cell development; BMP signaling pathway; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	10637
	13590
	ENSG00000243709
	ENSMUSG00000038793
	O75610
	Q64280
	NM_020997
	NM_010094
	NP_066277
	NP_034224
	Wikidata
View/Edit Human	View/Edit Mouse

Left-right determination factor 1 is a protein that in humans is encoded by the LEFTY1 gene. ^[5]

Function

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000243709 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038793 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Left-right determination factor 1". Retrieved 2016-08-03.

Left-right determination factor 1

Contents

Function

See also

References

Further reading