Lelio may refer to:
- Lélio, a 1831 work incorporating music and spoken text by the French composer Hector Berlioz
- Lélio (actor) (1676–1753), Italian actor and writer on theatre
- Lélio (Commedia dell'arte), a stock character of the commedia dell'arte
- Lelio (given name), a given name
- Sebastián Lelio (born 1974), Chilean film director and screenwriter