Leo the Lion may refer to:
- Leo the Lion (MGM), the mascot of the Hollywood film studio Metro-Goldwyn-Mayer
- Leo the Lion (TV series), a Japanese animated series by Osamu Tezuka
- Leo the Lion (2005 film), a 2005 Italian animated film
- Leo the Lion (singer), British singer Leo Ihenacho (born 1977)
- Leo the Lion, the Mascot of Real Salt Lake Soccer Team
- Leo "The Lion" Nomellini (1924–2000), American football player