Lettieri is an Italian surname. Notable people with the surname include:
- Al Lettieri (1928–1975), American actor
- Dave Lettieri (born 1964), American cyclist
- Gabriel Lettieri (born 1975), Argentine footballer
- Gino Lettieri (born 1966), Italian football manager
- Mark Lettieri (born c. 1984), American guitarist
- Paola Lettieri, British-Italian chemical engineer
- Tino Lettieri (born 1957), Italian footballer
- Vinni Lettieri (born 1995), American ice hockey player