Lexa is both a surname and a given name. Notable people with the name include:
Surname:
- Anthony Lexa, English actress and musician
- František Lexa (1876-1960), Czechoslovakian Egyptologist
- Stefan Lexa (born 1976), Austrian football (soccer) player
- Ivan Lexa (born 1961), Slovak politician and former head of the Secret Service
Given name:
- Lexa Doig (born 1973), Canadian actress
Fictional characters:
- Lexa Pierce, character in the television series Mutant X
- Lexa, the commander of the grounder clans in the TV series The 100