Linuron (3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea) is a phenylurea herbicide[1] that is used to control the growth of grass and weeds for the purpose of supporting the growth of crops like soybeans.[2][3]
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| ECHA InfoCard | 100.005.779 |
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| Formula | C9H10Cl2N2O2 |
| Molar mass | 249.09 g·mol−1 |
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Pharmacology
editMechanism of action
editLinuron acts via inhibition of photosystem II, which is necessary for photosynthetic electron transport in plants.[2][3]
Effects in animals
editLinuron has been found to produce reproductive toxicity in animals by acting as an androgen receptor (AR) antagonist, and for this reason, is considered to be an endocrine disruptor.[2][4] Consequently, in January 2017, the Standing Committee on Plants, Animals, Food and Feed (SCoPAFF) of the European Commission DG "Health and food safety" decided to not renew its regulatory approval.[5] Sales are expected to cease by June 2017.[5]
See also
editReferences
edit- ^ Maier-Bode H, Härtel K (1981). "Linuron and monolinuron". Residue Reviews. Reviews of Environmental Contamination and Toxicology. Vol. 77. pp. 1–364. doi:10.1007/978-1-4612-5874-2_1. ISBN 978-1-4612-5876-6. PMID 7017855.
- ^ a b c Mercurio S (30 August 2016). Understanding Toxicology. Jones & Bartlett Learning. pp. 705–. ISBN 978-1-284-12761-4.
- ^ a b Roberts TR (1998). Metabolic Pathways of Agrochemicals. Royal Society of Chemistry. pp. 744–. ISBN 978-0-85404-494-8.
- ^ "Peer review of the pesticide risk assessment of the active substance linuron". EFSA Journal. 14 (7). July 2016. doi:10.2903/j.efsa.2016.4518.
- ^ a b Curtis M. "Linuron fails to gain renewed approval". fginsight.com. Briefing Media Ltd. Archived from the original on 31 October 2021. Retrieved 24 May 2017.