Lipopolysaccharide N-acetylglucosaminyltransferase

In enzymology, a lipopolysaccharide N-acetylglucosaminyltransferase (EC 2.4.1.56) is an enzyme that catalyzes the chemical reaction

lipopolysaccharide N-acetylglucosaminyltransferase
Identifiers
EC no.2.4.1.56
CAS no.37277-64-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
UDP-N-acetyl-D-glucosamine + lipopolysaccharide UDP + N-acetyl-D-glucosaminyllipopolysaccharide

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and lipopolysaccharide, whereas its two products are UDP and N-acetyl-D-glucosaminyllipopolysaccharide.

This enzyme participates in lipopolysaccharide biosynthesis and glycan structures - biosynthesis 2.

Nomenclature

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This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase. Other names in common use include UDP-N-acetylglucosamine-lipopolysaccharide, N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-lipopolysaccharide, and acetylglucosaminyltransferase.

References

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  • Osborn MJ, D'Ari L (August 1964). "Enzymatic incorporation of N-acetylglucosamine into cell wall lipopolysaccharide in a mutant strain of Salmonella typhimurium". Biochemical and Biophysical Research Communications. 16 (6): 568–75. doi:10.1016/0006-291X(64)90194-9. PMID 5332855.