This is a list of films which have placed number one at the weekend box office in Brazil during 2010 (Amounts are in Brazilian reais; 1 real is approximately equivalent to 0.64 US dollars).
| Date | Film | Gross | Notes |
|---|---|---|---|
| 3 January | Avatar | R$6,503,268 | Most weeks at number one in 2010. |
| 10 January | Alvin and the Chipmunks: The Squeakquel | R$5,926,489 | |
| 17 January | Avatar | R$4,841,019 | |
| 24 January | R$4,391,362 | ||
| 31 January | R$3,870,667 | ||
| 7 February | R$2,700,815 | ||
| 14 February | Percy Jackson & the Olympians: The Lightning Thief | R$2,461,100 | |
| 21 February | Avatar | R$2,277,020 | |
| 28 February | Percy Jackson & the Olympians: The Lightning Thief | R$1,741,684 | |
| 7 March | Avatar | R$1,691,904 | |
| 14 March | Shutter Island | R$2,008,071 | |
| 21 March | The Book of Eli | R$1,942,202 | |
| 28 March | How to Train your Dragon | R$4,456,129 | |
| 4 April | Chico Xavier | R$6,154,017 | Brazilian film |
| 11 April | R$4,510,506 | ||
| 18 April | R$3,146,228 | ||
| 25 April | Alice in Wonderland | R$10,620,651 | |
| 2 May | Iron Man 2 | R$8,529,311 | |
| 9 May | Alice in Wonderland | R$5,804,311 | |
| 16 May | R$4,745,330 | ||
| 23 May | Clash of the Titans | R$7,462,813 | |
| 30 May | R$5,03,986 | ||
| 6 June | Prince of Persia: The Sands of Time | R$4,084,795 | |
| 13 June | R$2,858,391 | ||
| 20 June | Toy Story 3 | R$4.692.136 | |
| 27 June | R$6.149.734 | ||
| 4 July | The Twilight Saga: Eclipse | R$11.824.498 | |
| 11 July | Shrek Forever After | R$11.261.207 | |
| 18 July | R$10.603.073 | ||
| 25 July | R$8.044.733 | ||
| 1 August | R$5.995.478 | ||
| 8 August | Despicable Me | R$5.220.730 | |
| 15 August | R$4.643.141 | ||
| 22 August | The Last Airbender | R$4.463.523 | |
| 29 August | The Karate Kid | R$3.642.374 | |
| 5 September | Nosso Lar | R$5.749.371 | Brazilian film |
| 12 September | R$4.580.149 | ||
| 19 September | Resident Evil: Afterlife | R$5.092.093 | |
| 26 September | R$3.035.934 | ||
| 3 October | Eat Pray Love | R$3.513.946 | |
| 10 October | Tropa de Elite 2 | R$14.033.577 | Brazilian film; highest opening weekend of the year, and highest in 20 years; highest-grossing film and attendance ever in Brazil |
| 17 October | R$12.245.246 | ||
| 24 October | R$9.074.816 | ||
| 31 October | R$7.547.285 | ||
| 7 November | R$4.714.704 | ||
| 14 November | R$3.974.874 | ||
| 21 November | Harry Potter and the Deathly Hallows – Part 1 | R$12.020.492 | Highest opening weekend for a foreign movie of the year |
| 28 November | R$5.874.394 | ||
| 5 December | Megamind | R$3.912.189 | |
| 12 December | The Chronicles of Narnia: The Voyage of the Dawn Treader | R$4.484.102 | |
| 19 December | Tron: Legacy | R$3.086.462 | |
| 26 December | R$1.685.612 |