These are the songs that reached number one on the Top 100 Best Sellers chart in 1960 as published by Cash Box magazine.
| Issue Date | Song | Artist |
|---|---|---|
| January 2 | Why | Frankie Avalon |
| January 9 | ||
| January 16 | ||
| January 23 | Running Bear | Johnny Preston |
| January 30 | ||
| February 6 | ||
| February 13 | Teen Angel | Mark Dinning |
| February 20 | ||
| February 27 | Theme from "A Summer Place" | Percy Faith & Orchestra |
| March 5 | ||
| March 12 | ||
| March 19 | ||
| March 26 | ||
| April 2 | ||
| April 9 | ||
| April 16 | ||
| April 23 | Stuck On You | Elvis Presley |
| April 30 | ||
| May 7 | ||
| May 14 | ||
| May 21 | Cathy's Clown | The Everly Brothers |
| May 28 | ||
| June 4 | ||
| June 11 | ||
| June 18 | ||
| June 25 | Everybody's Somebody's Fool | Connie Francis |
| July 2 | ||
| July 9 | ||
| July 16 | Alley Oop | The Hollywood Argyles, Dante & the Evergreens |
| July 23 | I'm Sorry | Brenda Lee |
| July 30 | ||
| August 6 | Itsy Bitsy Teenie Weenie Yellow Polka Dot Bikini | Brian Hyland |
| August 13 | It's Now or Never | Elvis Presley |
| August 20 | ||
| August 27 | ||
| September 3 | ||
| September 10 | The Twist | Chubby Checker |
| September 17 | ||
| September 24 | ||
| October 1 | ||
| October 8 | My Heart Has a Mind of Its Own | Connie Francis |
| October 15 | Save the Last Dance for Me | The Drifters |
| October 22 | ||
| October 29 | ||
| November 5 | ||
| November 12 | ||
| November 19 | ||
| November 26 | Are You Lonesome Tonight? | Elvis Presley |
| December 3 | ||
| December 10 | ||
| December 17 | ||
| December 24 | ||
| December 31 |