† – Delta State's record is officially listed as 2–8 (1–7) due to the use of ineligible players in two wins, but the opponents are not credited with wins.
Notes: Due to COVID-19, the Gulf South Conference suspended the fall 2020 football season. The conference also announced no in-conference competition for spring 2021 play. Schools scheduled own games if desired to play. Delta State, North Greenville, Valdosta State, West Florida, and West Georgia opted out of the spring season.