List of The Big Bang Theory guest stars

This is a list of The Big Bang Theory guest stars. Most "played" themselves. The episodes in which they appeared are followed by the season in brackets.

Actors

• Sean Astin as Dr. Greg Pemberton
  • "The Confirmation Polarization" (12)
  • "The Laureate Accumulation" (12)
  • "The Plagiarism Schism" (12)
• Kathy Bates as Mrs. Fowler, Amy Farrah Fowler's mother
  • "The Bow Tie Asymmetry" (11)
  • "The Conjugal Configuration" (12)
  • "The Consummation Deviation" (12)
• LeVar Burton
  • "The Toast Derivation" (4)
  • "The Habitation Configuration" (6)
  • "The Champagne Reflection" (8)
• Keith Carradine as Wyatt, Penny's father
  • "The Boyfriend Complexity" (4)
  • "The Bachelor Party Corrosion" (9)
  • "The Conjugal Conjecture" (10)
  • "The Procreation Calculation" (12)
  • "The Donation Oscillation" (12)
• Eliza Dushku as FBI Special Agent Angela Page
  • "The Apology Insufficiency" (4)
• Nathan Fillion
  • "The Comic Book Store Regeneration" (8)
• Carrie Fisher
  • "The Convention Conundrum" (7)
• Sarah Michelle Gellar
  • "The Stockholm Syndrome" (12)
• Summer Glau
  • "The Terminator Decoupling" (2)
• Judy Greer as Dr. Elizabeth Plimpton
  • "The Plimpton Stimulation" (3)
• Mark Hamill
  • "The Bow Tie Asymmetry" (11)
• Courtney Henggeler as Missy, Sheldon's sister
  • "The Pork Chop Indeterminancy" (1)
  • "The Bow Tie Asymmetry" (11)
• James Earl Jones
  • "The Convention Conundrum" (7)
• Christopher Lloyd as Theodore, to whom Sheldon sublets his room
  • "The Property Division Collision" (10)
• Joe Manganiello
  • "The D&D Vortex" (12)
• Danica McKellar as Abby
  • "The Psychic Vortex" (3)
• Leonard Nimoy
  • "The Transporter Malfunction" (5, voice)
• Jerry O'Connell as George Cooper Jr., Sheldon's older brother
  • "The Sibling Realignment" (11)
  • "The Bow Tie Asymmetry" (11)
  • "The Tam Turbulence" (12)
• Jodi Lyn O'Keefe as Mikayla, a prostitute
  • "The Vegas Renormalization" (2)
• Kal Penn as Dr. Kevin Campbell
  • "The Confirmation Polarization" (12)
  • "The Laureate Accumulation" (12)
  • "The Plagiarism Schism" (12)
• Katee Sackhoff
  • "The Vengeance Formulation" (3)
  • "The Hot Troll Deviation" (4)
• Charlie Sheen
  • "The Griffin Equivalency" (2)
• William Shatner
  • "The D&D Vortex" (12)
• Kevin Smith
  • "The Fortification Implementation" (8)
  • "The D&D Vortex" (12)
• Octavia Spencer as a Department of Motor Vehicles employee
  • "The Euclid Alternative" (2)
• Brent Spiner
  • "The Russian Rocket Reaction" (5)
• June Squibb as Meemaw, Sheldon's grandmother
  • "The Meemaw Materialization" (9)
• George Takei
  • "The Hot Troll Deviation" (4)
• Billy Bob Thornton as Dr. Oliver Lorvis
  • "The Misinterpretation Agitation" (8)
• Analeigh Tipton
  • "The Panty Piñata Polarization" (2)
• Jessica Walter as Mrs. Latham, a philanthropist
  • "The Benefactor Factor" (4)
• Adam West
  • "The Celebration Experimentation" (9)
• Steven Yeun
  • "The Staircase Implementation" (3)

Athletes

• Kareem Abdul-Jabbar
  • "The D&D Vortex" (12)
• Rick Fox as Glenn, Bernadette's ex-boyfriend
  • "The Love Car Displacement" (4)

Astronauts

• Buzz Aldrin
  • "The Holographic Excitation" (6)
• Mike Massimino
  • "The Friendship Contraction" (5)
  • "The Countdown Reflection" (5)
  • "The Decoupling Fluctuation" (6)
  • "The Re-Entry Minimization" (6)
  • "The Table Polarization" (7)
  • "The First Pitch Insufficiency" (8)

Comedians

• Lewis Black as Professor Crawley
  • "The Jiminy Conjecture" (3)
• Ellen DeGeneres
  • "The Geology Elevation" (10)
  • "The Laureate Accumulation" (12)
• Howie Mandel
  • "The Re-entry Minimization" (6)
• Teller as Mr. Fowler, Amy Farrah Fowler's father
  • "The Bow Tie Asymmetry" (11)
  • "The Conjugal Configuration" (12)
  • "The Consummation Deviation" (12)

Entrepreneurs

• Bill Gates
  • "The Gates Excitation" (11)
• Elon Musk
  • "The Platonic Permutation" (9)
• Steve Wozniak
  • "The Cruciferous Vegetable Amplification" (4)

Scientists

• Frances Arnold
  • "The Laureate Accumulation" (12)
• Brian Greene
  • "The Herb Garden Germination" (4)
• Stephen Hawking
  • "The Hawking Excitation" (5)
  • "The Extract Obliteration" (6, voice)
  • "The Relationship Diremption" (7, voice)
  • "The Troll Manifestation" (8)
  • "The Celebration Experimentation" (9)
  • "The Geology Elevation" (10)
  • "The Proposal Proposal" (11)
• George Smoot
  • "The Laureate Accumulation" (12)
• Kip Thorne
  • "The Laureate Accumulation" (12)
• Neil deGrasse Tyson
  • "The Apology Insufficiency" (4)
  • "The Conjugal Configuration" (12)

Others

• Adam Nimoy
  • "The Spock Resonance" (9)
• Ira Flatow
  • "The Vengeance Formulation" (3, voice)
  • "The Discovery Dissipation" (7)
  • "The Retraction Reaction" (11)
• Neil Gaiman
  • "The Comet Polarization" (11)
• Stan Lee
  • "The Excelsior Acquisition" (3)
• Bill Nye
  • "The Proton Displacement" (7)
  • "The Conjugal Configuration" (12)