These singles topped the Ultratop 50 in 2010.[1]
| Issue Date | Song | Artist |
|---|---|---|
| 2 January | "Meet Me Halfway" | The Black Eyed Peas |
| 9 January | ||
| 16 January | "Envoi" | Absynthe Minded |
| 23 January | ||
| 30 January | "Heads Will Roll" | Yeah Yeah Yeahs |
| 6 February | "Hallelujah" | Natalia and Gabriel Ríos |
| 13 February | ||
| 20 February | ||
| 27 February | "We Are the World 25 for Haiti" | Artists for Haiti |
| 6 March | "Storm" | Milk Inc. |
| 13 March | "Hallelujah" | Natalia and Gabriel Ríos |
| 20 March | ||
| 27 March | "Me and My Guitar" | Tom Dice |
| 3 April | "Telephone" | Lady Gaga featuring Beyoncé |
| 10 April | ||
| 17 April | ||
| 24 April | ||
| 1 May | ||
| 8 May | "Alors on danse" | Stromae |
| 15 May | ||
| 22 May | ||
| 29 May | "Dos cervezas" | Tom Waes |
| 5 June | "Me and My Guitar" | Tom Dice |
| 12 June | ||
| 19 June | "Alors on danse" | Stromae |
| 26 June | "Waka Waka" | Shakira featuring Freshlyground |
| 3 July | ||
| 10 July | ||
| 17 July | "We No Speak Americano" | Yolanda Be Cool vs. DCUP |
| 24 July | "Waka Waka" | Shakira featuring Freshlyground |
| 31 July | "We No Speak Americano" | Yolanda Be Cool vs. DCUP |
| 7 August | ||
| 14 August | ||
| 21 August | ||
| 28 August | "Waka Waka" | Shakira featuring Freshlyground |
| 4 September | "No Sound But the Wind" | Editors |
| 11 September | ||
| 18 September | "Bromance" | Tim Berg |
| 25 September | "Love the Way You Lie" | Eminem featuring Rihanna |
| 2 October | "I Need a Dollar" | Aloe Blacc |
| 9 October | ||
| 16 October | "Barbra Streisand" | Duck Sauce |
| 23 October | ||
| 30 October | ||
| 6 November | ||
| 13 November | ||
| 20 November | ||
| 27 November | "The Time (Dirty Bit)" | The Black Eyed Peas |
| 4 December | ||
| 11 December | ||
| 18 December | ||
| 25 December |