Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. Adaptins are clustered subunits of adaptor protein (AP) complexes.[1] There are several types of adaptin, each related to a different AP complex.

Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin.[1] The adaptin is a heterotetramer consisting of two large adaptins (beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma):

A diagram of the 5 complexes is shown here

References

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  1. ^ a b Boehm, Markus; Bonifacino, Juan S. (October 2001). "Adaptins". Molecular Biology of the Cell. 12 (10): 2907–2920. doi:10.1091/mbc.12.10.2907. ISSN 1059-1524. PMC 60144. PMID 11598180.
  2. ^ Mattera, Rafael; Guardia, Carlos M.; Sidhu, Sachdev S.; Bonifacino, Juan S. (2015). "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". Journal of Biological Chemistry. 290 (52): 30736–30749. doi:10.1074/jbc.M115.683409. PMC 4692204. PMID 26542808.