A
edit- Russ Abbot, actor, musician
B
edit- Reg Barton, footballer
- Diana Beck, neurosurgeon
- Stan Bennion, footballer
- Chris Blackburn, footballer
- Emily Booth, actress
- Grenville Booth, footballer
- Sir Adrian Boult, orchestral conductor
- Thomas Brassey, civil engineer, railway contractor
- David Brett, footballer
- Oswald Walters Brierly, Marine painter to Queen Victoria
- Robert Butt, footballer
C
edit- Hall Caine, (1853–1931), writer
- Randolph Caldecott, illustrator and artist
- Thomas E. Caldecott, politician
- Ray Carter, footballer
- Mark Cartwright, footballer
- Hugh B. Cave, author
- Gerald Cavendish Grosvenor, Duke of Westminster
- Mike Cecere, footballer
- Dave Challinor, footballer
- Ron Chesterman, musician
- Nigel Clutton, footballer
- Danny Collins (footballer), footballer
- Alec Croft, footballer
- Brian Croft, footballer
- Daniel Craig, actor (James Bond series)
- Emma Cunniffe, actress
D
edit- John Douglas, (1830–1911), architect
E
editF
edit- Tony Field (footballer born 1942)
- Mike Fields, footballer
- Graham, Paul, and Ron Futcher, brothers who all played professional football
G
edit- Keith Griffiths, footballer
H
edit- Albert and Les Harley, footballing brothers
- Thomas Harrison, architect
- Tom Heaton, footballer
- Malcolm Hebden, actor
- Joe Hewitt, footballer
- Randle Holme - name shared by four successive generations of a family of herald painters
- A. S. Hornby, lexicographer
- Barry Horne, footballer
- Robert Spear Hudson (businessman)
- Tom Hughes, actor
I
edit- Jerry Ireland, footballer
J
editK
editL
edit- Lee Latchford-Evans, singer
- Eric Lee (footballer)
- Bert Lipsham, footballer
- Hugh Lloyd, actor
- Frank Eric Lloyd, author of Rhodesian Patrol
M
edit- Levi Mackin, footballer
- George Mainwaring, merchant, mayor and MP
- Lucy Meacock, broadcaster
- Bob Mills (comedian)
- Helen Modern, actress
- William Monk, etcher, woodcut engraver and painter
- Steve Moore (footballer)
- Alan Morris (footballer)
- Jill Morris, diplomat
- William De Morgan, potter and tile designer
- Spangles Muldoon, DJ
- Danny Murphy (footballer born 1977), footballer
O
edit- Stephen Oliver, composer
- Michael Owen, footballer
P
edit- Mike Parry, broadcaster
- Ronald Pickup, actor
- John Port (the elder), judge
- Gary Potter, footballer
- Graham Pugh, footballer
R
edit- Basil Radford, actor
- Paul Raynor (footballer born 1957)
- Bill Rigby footballer
- L. T. C. Rolt, biographer, engineer, writer and canal enthusiast
- Gary Roberts (footballer born 1984)
- Gary Roberts (footballer born 1987)
- Martin Roscoe (b. 1952), classical pianist
- Adam Rickitt (singer and actor)
S
edit- Ian Saltmarsh, cricketer.
- Alex Sanderson, Rugby union player
- Harry Smith, footballer
- George Spruce, footballer
- John Steiner, actor
- Ryan Shawcross, footballer
T
edit- John Thompson, cricketer
- Anthony Thwaite, poet
- Charles John Tibbits, journalist, newspaper editor, author, and legal writer
- Beatrice Tinsley, cosmologist
- Beth Tweddle, gymnast
- Martin Tyler, football commentator
V
edit- Danny Ventre, footballer
W
edit- Robert Wilcox (martyr)
- Helen Willetts, weather presenter and former international badminton player
- Brian Woodall, footballer