Listeria Hfq binding LhrA is a ncRNA that was identified by screening for RNA molecules which co-immunoprecipitated with the RNA chaperone Hfq.[1] This RNA is transcribed from a region overlapping with a predicted protein of unknown function (Lmo2257) and is located between a putative intracellular protease and a putative protein of the ribulose-phosphate 3 epimerase family. It is highly expressed in the stationary growth phase but the function is unknown. It is proposed to be a regulatory RNA which controls gene expression at the post transcriptional level by binding the target mRNA in an Hfq dependent fashion. This RNA molecule appears to be conserved amongst Listeria species but has not been identified in other bacterial species.
| Listeria Hfq binding LhrA | |
|---|---|
 Predicted secondary structure and sequence conservation of LhrA | |
| Identifiers | |
| Symbol | LhrA |
| Rfam | RF00615 |
| Other data | |
| RNA type | Gene; sRNA |
| Domain(s) | Bacteria |
| GO | GO:0003729 |
| SO | SO:0000655 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Christiansen JK, Nielsen JS, Ebersbach T, Valentin-Hansen P, Søgaard-Andersen L, Kallipolitis BH (2006). "Identification of small Hfq-binding RNAs in Listeria monocytogenes". RNA. 12 (7): 1383–1396. doi:10.1261/rna.49706. PMC 1484441. PMID 16682563.
External links
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