Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).[5]

NR1H2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR, Liver X receptor beta, nuclear receptor subfamily 1 group H member 2
External IDsOMIM: 600380; MGI: 1352463; HomoloGene: 21397; GeneCards: NR1H2; OMA:NR1H2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007121
NM_001256647

NM_001285517
NM_001285518
NM_001285519
NM_009473

RefSeq (protein)

NP_001243576
NP_009052
NP_009052.3

NP_001272446
NP_001272447
NP_001272448
NP_033499

Location (UCSC)Chr 19: 50.33 – 50.38 MbChr 7: 44.2 – 44.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA) and beta, are known to encode LXR proteins.[5][6]

Structure

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Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. The LXRβ core binds DNA via canonical contacts and auxiliary DNA contacts that enhance affinity for the response element.[7]

Interactions

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Liver X receptor beta has been shown to interact with NCOA6[8] and Retinoid X receptor alpha.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131408Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060601Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2".
  6. ^ Song C, Hiipakka RA, Kokontis JM, Liao S (Jun 1995). "Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones". Annals of the New York Academy of Sciences. 761 (2): 38–49. Bibcode:1995NYASA.761...38S. doi:10.1111/j.1749-6632.1995.tb31367.x. PMID 7625741. S2CID 27208069.
  7. ^ Lou X, Toresson G, Benod C, Suh JH, Philips KJ, Webb P, Gustafsson JA (Mar 2014). "Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA". Nature Structural & Molecular Biology. 21 (3): 277–81. doi:10.1038/nsmb.2778. PMID 24561505. S2CID 23226682.
  8. ^ Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (Feb 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Molecular Endocrinology. 15 (2): 241–54. doi:10.1210/mend.15.2.0595. PMID 11158331.
  9. ^ Seol W, Choi HS, Moore DD (Jan 1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors". Molecular Endocrinology. 9 (1): 72–85. doi:10.1210/mend.9.1.7760852. PMID 7760852.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.