Lon peptidase 2, peroxisomal

Lon peptidase 2, peroxisomal is a protein that in humans is encoded by the LONP2 gene. [5]

LONP2
Identifiers
AliasesLONP2, LONP, LONPL, lon peptidase 2, peroxisomal, PLON, PSLON
External IDsOMIM: 617774; MGI: 1914137; HomoloGene: 12050; GeneCards: LONP2; OMA:LONP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300948
NM_031490
NM_001348078

NM_001168591
NM_025827

RefSeq (protein)

NP_001287877
NP_113678
NP_001335007

NP_001162063
NP_080103

Location (UCSC)Chr 16: 48.24 – 48.36 MbChr 8: 87.35 – 87.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102910Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047866Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Lon peptidase 2, peroxisomal". Retrieved 2017-12-04.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.