Long-chain fatty acid transport protein 4

Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene.[5][6] This membrane protein is also called FATP4 or ACSVL5 (very long chain fatty acyl-CoA synthetase 5). The purified protein shows enzyme activity (EC 6.2.1.3), esterifying long and very long chain fatty acids with Coenzyme A.[7] It is debated whether it is also a fatty acid transporter at the plasma membrane.[8]

SLC27A4
Identifiers
AliasesSLC27A4, ACSVL4, FATP4, IPS, solute carrier family 27 member 4
External IDsOMIM: 604194; MGI: 1347347; HomoloGene: 68437; GeneCards: SLC27A4; OMA:SLC27A4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005094

NM_011989

RefSeq (protein)

NP_005085
NP_005085.2

NP_036119

Location (UCSC)Chr 9: 128.34 – 128.36 MbChr 2: 29.69 – 29.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167114Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059316Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fitscher BA, Riedel HD, Young KC, Stremmel W (Dec 1998). "Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 381–5. doi:10.1016/s0167-4781(98)00231-0. PMID 9878842.
  6. ^ "Entrez Gene: SLC27A4 solute carrier family 27 (fatty acid transporter), member 4".
  7. ^ Hall AM, Wiczer BM, Herrmann T, Stremmel W, Bernlohr DA (Mar 2005). "Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice". The Journal of Biological Chemistry. 280 (12): 11948–54. doi:10.1074/jbc.M412629200. PMID 15653672.
  8. ^ Watkins PA (Jan 2008). "Very-long-chain acyl-CoA synthetases". The Journal of Biological Chemistry. 283 (4): 1773–7. doi:10.1074/jbc.R700037200. PMID 18024425.

Further reading

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