Lopresti is an Italian surname, also written LoPresti or Lo Presti. Notable people with the surname include:
- Aaron Lopresti (born 1964), an American comic book artist
- Charles LoPresti (born 1957), an American race horse trainer
- Danielle LoPresti (born 1969), American musician
- Matthew LoPresti, an American academic and politician
- Mike Lopresti (born 1953), an American sportswriter
- Jack Lopresti (born 1969), a British politician
- Jaime Lopresti (born 1974), a Chilean footballer
- Anna Banti (1895–1985), an Italian writer, art historian, critic, and translator, born Lucia Lopresti
- Pete LoPresti (born 1954), an American ice hockey player, son of Sam
- Peter Essex-Lopresti (1916–1951), a British orthopaedic surgeon
- Rodrigo Lopresti (born 1976), an American actor, director, and musician
- Rocco Lo Presti (1937–2009), an Italian mob boss of the Lo Presti 'ndrina
- Roy LoPresti (1929–2002), an American aeronautical engineer
- Sam LoPresti (1917–1984), an American ice hockey player, father of Pete
- Mike Lopresti (born 1981), Internet personality