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The lowest-observed-adverse-effect level (LOAEL), or the lowest-observed-adverse-effect concentration (LOAEC), is the lowest concentration or amount of a substance found by experiment or observation that causes an adverse alteration of morphology, function, capacity, growth, development, or lifespan of a target organism distinguished from normal organisms of the same species under defined conditions of exposure.[1] Federal agencies use the LOAEL during risk assessment to set approval standards below this level.[2]
The United States Environmental Protection Agency defines LOAEL as the 'lowest level of a chemical stressor evaluated in a toxicity test that shows harmful effects on a plant or animal. While LOAELs and LOAECs are similar, they are not interchangeable. A LOAEL refers to a dose of chemical that is ingested, while a LOAEC refers to direct exposure to a chemical (e.g., through gills or the skin).[3]
See also
editReferences
edit- ^ "IUPAC glossary of terms used in toxicology - terms starting with L". Environmental Health and Toxicology Specialized Information Services. U.S. Department of Health & Human Services. Retrieved January 9, 2016. based upon Duffus, J. H.; Nordberg, M.; Templeton, D. M. (2007). "Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)". Pure and Applied Chemistry. 79 (7): 1153. doi:10.1351/pac200779071153.
- ^ NIOSH (March 2020). NIOSH Practices in Occupational Risk Assessment. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. Publication No. 2020-106. doi:10.26616/NIOSHPUB2020106. Retrieved 18 July 2024.
- ^ Registries, EPA, OEI, SOR, System Of. "Terms & Acronyms".
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This article incorporates public domain material from Jasper Womach. Report for Congress: Agriculture: A Glossary of Terms, Programs, and Laws, 2005 Edition (PDF). Congressional Research Service.
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